The last time the Buffalo Bills played the New York Jets, quarterback EJ Manuel targeted Stevie Johnson and Robert Woods 23 times.
Johnson and Woods have been ruled out for Sunday's rematch in Ralph Wilson Stadium.
Bills coach Doug Marrone said they would go with their four healthy receivers.
T.J. Graham, Marquise Goodwin, Chris Hogan and Marcus Easley will need to pick up the slack. Goodwin is the only one of that group with a touchdown this year. Easley made his first NFL catch last week.
Tight ends Scott Chandler and Chris Gragg will be even more important. Gragg also caught his first NFL passes last Sunday, but one of them was a touchdown.
Johnson leads the Bills with 41 catches, 471 yards and three touchdowns. Woods is second among wide receivers with 26 catches, 349 yards and two touchdowns.