Bills safety Aaron Williams left the game with injured ribs with 9:21 left in the fourth quarter. He was replaced by Da'Norris Searcy.

Defensive tackle Marcell Dareus also left the game with an ankle injury. He did not return.

Receiver Marquise Goodwin was shaken up after taking a hit to the head from Jaguars safety Winston Guy with 12:42 left. Guy was penalized for unnecessary roughness.